Characterization of a Recent Patient derived Murray Valley Encephalitis Virus Isolate

Project Summary

Murray Valley Encepaphalitis Virus (MVE) is a member of the family Flaviviridae. Infection with this virus is associated with significant morbidity and mortality in those that exhibit symptoms. Approximately 1/400-1000 people infected with the virus exhibit symptoms. This virus is endemic to Australia and has been associated with large historical outbreaks. MVE is difficult to isolate and it has been reported that there have been no isolations of this virus from humans since 1974.

VIDRL have recently detected their first MVE positive patient by PCR and have successfully isolated MVE from this patient's CSF. This project therefore aims to sequence the full genome of this isolate to update and compare it to the limited number of historical full length genomes of this virus.  Obtaining the full genome sequence of this rare human derived isolate of MVE will provide useful information on the sequence of the virus, which will be useful for future research, immunological studies, and potential public health and epidemiological purposes.

Project Partner

VIDRL

Project Team

Dr Matthew Kaye

Dr Glen Carter

A/Prof Timothy Stinear

Dr Julian Druce