Determining Antimicrobial Resistance in Neisseria gonorrhoeae Using Whole Genome Sequencing

Project Summary

Neisseria gonorrhoeae is the causative agent of gonorrhea, an important sexually transmitted infection of humans, which places a large economic burden on the Australian healthcare system. If left untreated gonorrhea can cause serious and permanent health problems such as pelvic inflammatory disease and infertility in women and epididymitis and sterility in men.  Importantly, untreated N. gonnorrhoeae is associated with an increased risk of HIV.

Antibiotic resistance is widespread in N. gonorrhoeae meaning that in some cases treatment options have become limited.  This has led to the US Centres for Disease Control (CDC) classifying drug-resistant N. gonorrhoeae as an urgent threat to human health.

This project aims to use next generation sequencing to characterize a collection of N. gonorrhoeae isolates collected in New Zealand using in silico NG-MAST and to determine the prevalence of antibiotic resistance genes genes in these isolates.

Project Partner

The Institute of Environmental Science and Research, New Zealand

Project Team

Dr Deborah Williamson

Dr Glen Carter

A/Prof Torsten Seemann

Prof Ben Howden

Research Program

Antimicrobial Resistance