Determining Antimicrobial Resistance in Neisseria gonorrhoeae Using Whole Genome Sequencing
Neisseria gonorrhoeae is the causative agent of gonorrhea, an important sexually transmitted infection of humans, which places a large economic burden on the Australian healthcare system. If left untreated gonorrhea can cause serious and permanent health problems such as pelvic inflammatory disease and infertility in women and epididymitis and sterility in men. Importantly, untreated N. gonnorrhoeae is associated with an increased risk of HIV.
Antibiotic resistance is widespread in N. gonorrhoeae meaning that in some cases treatment options have become limited. This has led to the US Centres for Disease Control (CDC) classifying drug-resistant N. gonorrhoeae as an urgent threat to human health.
This project aims to use next generation sequencing to characterize a collection of N. gonorrhoeae isolates collected in New Zealand using in silico NG-MAST and to determine the prevalence of antibiotic resistance genes genes in these isolates.
The Institute of Environmental Science and Research, New Zealand
Dr Deborah Williamson
Dr Glen Carter
A/Prof Torsten Seemann
Prof Ben Howden